Solute effects on spin labels at an aqueous-exposed site in the flap region of HIV-1 protease.

Abstract

The effects of solutes on spin-label mobility and protein conformation have been investigated with X-band continuous-wave and pulsed electron paramagnetic resonance (EPR) spectroscopy for spin labels attached to an aqueous-exposed site in the beta-hairpin flap region of HIV-1 protease. Specifically, we examined the effects of glycerol, sucrose, PEG3000, and… (More)
DOI: 10.1021/jp8057788

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