Solute and macromolecule diffusion in cellular aqueous compartments.

  title={Solute and macromolecule diffusion in cellular aqueous compartments.},
  author={Alan S. Verkman},
  journal={Trends in biochemical sciences},
  volume={27 1},
Diffusion of solutes and macromolecules in aqueous cellular compartments is required for numerous cellular processes including metabolism, second messenger signaling and protein-protein interactions. The view of the cell interior has evolved from that of a viscous gel to that of a watery but crowded compartment. Recent measurements of fluorescent probe diffusion using photobleaching, correlation microscopy and time-resolved anisotropy methods, have indicated unexpectedly high mobilities of… CONTINUE READING
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