Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.

  title={Soluble vascular adhesion protein-1 accumulates in proliferative diabetic retinopathy.},
  author={Miyuki Murata and Kousuke Noda and Junichi Fukuhara and Atsuhiro Kanda and Satoru Kase and Wataru Saito and Yoko Ozawa and Satsuki Mochizuki and Shioko Kimura and Yukihiko Mashima and Yasunori Okada and Susumu Ishida},
  journal={Investigative ophthalmology & visual science},
  volume={53 7},
PURPOSE Vascular adhesion protein (VAP)-1, a multifunctional molecule with adhesive and enzymatic properties, is expressed at the surface of vascular endothelial cells of mammals. It also exists as a soluble form (sVAP-1), which is implicated in oxidative stress via its enzymatic activity. This study explores a link between increased level of sVAP-1 and oxidative stress in proliferative diabetic retinopathy (PDR) with a focus on mechanistic components to form sVAP-1 by shedding from retinal… CONTINUE READING
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