Soluble uric acid increases NALP3 inflammasome and interleukin-1β expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway.

@article{Xiao2015SolubleUA,
  title={Soluble uric acid increases NALP3 inflammasome and interleukin-1$\beta$ expression in human primary renal proximal tubule epithelial cells through the Toll-like receptor 4-mediated pathway.},
  author={J. Xiao and Xiaoli Zhang and Chensheng Fu and R. Han and Weijun Chen and Y. Lu and Z. Ye},
  journal={International journal of molecular medicine},
  year={2015},
  volume={35 5},
  pages={
          1347-54
        }
}
Urate crystals activate innate immunity through Toll like receptor 4 (TLR4) activation, leading to the formation of the NACHT, LRR and PYD domains-containing protein 3 [NALP3; also known as NOD-like receptor family, pyrin domain containing 3 (NALP3) and cryopyrin] inflammasome, caspase-1 activation and interleukin (IL)-1β expression in gout. However, whether elevated serum uric acid (UA) levels are associated with the development and progression of renal diseases without renal urate crystal… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Roles of Toll-Like Receptors in C-C Chemokine Production by Renal Tubular Epithelial Cells1
AGE-LDL Activates Toll Like Receptor 4 Pathway and Promotes Inflammatory Cytokines Production in Renal Tubular Epithelial Cells
Uric Acid Induces Renal Inflammation via Activating Tubular NF-κB Signaling Pathway
Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy.
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
...
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3
4
5
...