Soluble tumor necrosis factor receptors correlate with parasitemia and disease severity in human malaria.

@article{Kern1992SolubleTN,
  title={Soluble tumor necrosis factor receptors correlate with parasitemia and disease severity in human malaria.},
  author={Peter Kern and Ch. J. Hemmer and Harald Gallati and Stefan Neifer and Peter Gottfried Kremsner and Manfred Dietrich and Franz Porzsolt},
  journal={The Journal of infectious diseases},
  year={1992},
  volume={166 4},
  pages={930-4}
}
Elevated serum or plasma concentration of immunoreactive tumor necrosis factor (TNF) is consistently detected in patients with malaria. TNF levels correlate with high parasitemia and clinical severity but not always with outcome. Since the effects of TNF may be neutralized by soluble TNF receptors, sera of 30 nonimmune patients with malaria were analyzed before and during antimalarial therapy. High concentrations of receptors R1 (55 kDa) and R2 (75 kDa) were detected immunologically in all sera… CONTINUE READING

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