Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells.

@article{Ishii1991SolubleTA,
  title={Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells.},
  author={Hiroaki Ishii and Hirohide Uchiyama and Mutsuyoshi Kazama},
  journal={Thrombosis and haemostasis},
  year={1991},
  volume={65 5},
  pages={618-23}
}
Thrombomodulin (TM) exists not only in endothelial cells but also in circulating plasma as soluble heterogeneous fragments. A release mechanism of soluble TM antigen from endothelial cells was investigated. Cultured human umbilical vein endothelial cells released about 0.6% of total cellular TM antigen into conditioned medium during 24 h. The release of TM antigen was not influenced by addition of various concentrations (0.01-5.0 microM) of monensin, which inhibits intracellular transport of… CONTINUE READING

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