Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsackievirus b3-mediated pancreatitis and myocarditis in mice.

@article{Yanagawa2004SolubleRC,
  title={Soluble recombinant coxsackievirus and adenovirus receptor abrogates coxsackievirus b3-mediated pancreatitis and myocarditis in mice.},
  author={Bobby Yanagawa and Owen B Spiller and David G Proctor and Jonathan Choy and Honglin Luo and Huifang Mary Zhang and Agripina C Suarez and Decheng Yang and Bruce McManus},
  journal={The Journal of infectious diseases},
  year={2004},
  volume={189 8},
  pages={1431-9}
}
BACKGROUND Group B coxsackievirus infection can result in organ injury and inflammation. The coxsackievirus and adenovirus receptor (CAR) and decay-accelerating factor (DAF; CD55) have both been identified as receptors for coxsackievirus B3 (CVB3). We have shown elsewhere that early DAF-Fc treatment attenuates CVB3-induced myocarditis and virus replication. METHODS CAR was synthesized as a soluble IgG1-Fc fusion protein (CAR-Fc). In vitro, CAR-Fc blocked infection by 2 different strains of… CONTINUE READING

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