Soluble recombinant HTLV-1 surface glycoprotein competitively inhibits syncytia formation and viral infection of cells.

@article{Jassal2001SolubleRH,
  title={Soluble recombinant HTLV-1 surface glycoprotein competitively inhibits syncytia formation and viral infection of cells.},
  author={Sushma R Jassal and Michael D. Lairmore and Andrew J. Leigh-Brown and David W. Brighty},
  journal={Virus research},
  year={2001},
  volume={78 1-2},
  pages={17-34}
}
Efficient entry into, and infection of, human cells by human T-cell leukaemia virus type-1 (HTLV-1) is mediated by the viral envelope glycoproteins, gp46 and gp21. The gp46 surface glycoprotein binds to an as yet unidentified cell surface receptor, thereby, allowing the gp21 transmembrane glycoprotein to initiate fusion of the viral and cellular membranes. In the absence of membrane fusion viral penetration and entry into the host cell cannot occur. The envelope glycoproteins are also a major… CONTINUE READING

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