Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system.

@article{Guo2016SolubleRF,
  title={Soluble receptor for advanced glycation end-products protects against ischemia/reperfusion-induced myocardial apoptosis via regulating the ubiquitin proteasome system.},
  author={Caixia Guo and Xue Jiang and Xiang-jun Zeng and Hong-xia Wang and Hui-hua Li and Feng-he Du and Buxing Chen},
  journal={Free radical biology & medicine},
  year={2016},
  volume={94},
  pages={17-26}
}
AIM Apoptosis participated in the pathological process of myocardial ischemia/reperfusion (I/R) injury. Previous studies have reported that endogenous substance sRAGE protect against I/R injury through inhibiting myocardial apoptosis. But the mechanisms are currently unknown. Prior work has demonstrated that ubiquitin proteasome system (UPS) dysfunction is closely related to apoptosis. We explored the potential role of UPS in the effect of sRAGE inhibition on I/R-induced myocardial apoptosis… CONTINUE READING
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