Soluble receptor for advanced glycation end-products enhanced the production of IFN-γ through the NF-κB pathway in macrophages recruited by ischemia/reperfusion.

  title={Soluble receptor for advanced glycation end-products enhanced the production of IFN-$\gamma$ through the NF-$\kappa$B pathway in macrophages recruited by ischemia/reperfusion.},
  author={Xiu-ling Zhang and Xianxian Cao and M. Dang and Hongxia Wang and Buxing Chen and Fenghe Du and Huihua Li and Xiangjun Zeng and Caixia Guo},
  journal={International journal of molecular medicine},
  volume={43 6},
The current study investigated the role of sRAGE in the production of IFN‑γ in macrophages with I/R treatment. The number of macrophages in myocardial tissues treated with I/R with or without sRAGE was determined via immunohistochemical staining. Proliferative activity of macrophages was analyzed by a 5‑BrdU incorporation assay. Differentiation of macrophages was detected via immunofluorescence staining of iNOS (M1 macrophage marker). IFN‑γ production, due to sRAGE stimulation, in Raw 264.7… Expand
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