Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target.

@article{Geroldi2006SolubleRF,
  title={Soluble receptor for advanced glycation end products: from disease marker to potential therapeutic target.},
  author={Diego Geroldi and Colomba Falcone and Enzo Emanuele},
  journal={Current medicinal chemistry},
  year={2006},
  volume={13 17},
  pages={
          1971-8
        }
}
The receptor for advanced glycation end products (RAGE) is a cell-bound receptor of the immunoglobulin superfamily which may be activated by a variety of proinflammatory ligands including advanced glycoxidation end products, S100/calgranulins, high mobility group box 1, and amyloid beta-peptide. RAGE has a secretory splice isoform, soluble RAGE (sRAGE), that lacks the transmembrane domain and therefore circulates in plasma. By competing with cell-surface RAGE for ligand binding, sRAGE may… CONTINUE READING

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