Soluble receptor for advance glycation end‐products inhibits ischemia/reperfusion‐induced myocardial autophagy via the STAT3 pathway

  title={Soluble receptor for advance glycation end‐products inhibits ischemia/reperfusion‐induced myocardial autophagy via the STAT3 pathway},
  author={M. Dang and Xiangjun Zeng and Buxing Chen and Hongxia Wang and Huihua Li and Y. Liu and Xiu-ling Zhang and Xianxian Cao and Fenghe Du and Caixia Guo},
  journal={Free Radical Biology and Medicine},
ABSTRACT The pathogenesis of myocardial ischemia/reperfusion (I/R) is poorly understood, but recent evidence suggests that autophagy plays crucial roles in I/R injuries. Soluble receptor for advanced glycation end‐products (sRAGE) exerts protective effects during I/R by decreasing cardiac apoptosis, which is mediated via increasing the ubiquitin proteasome system (UPS) and signal transducer and activator of transcription 3 (STAT3). The present study examined the effects and mechanisms of sRAGE… Expand
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