Soluble plasma HLA peptidome as a potential source for cancer biomarkers.

@article{BassaniSternberg2010SolublePH,
  title={Soluble plasma HLA peptidome as a potential source for cancer biomarkers.},
  author={Michal Bassani-Sternberg and Eilon Barnea and Ilan Beer and Irit Avivi and Tami Katz and Arie Admon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 44},
  pages={18769-76}
}
The HLA molecules are membrane-bound transporters that carry peptides from the cytoplasm to the cell surface for surveillance by circulating T lymphocytes. Although low levels of soluble HLA molecules (sHLA) are normally released into the blood, many types of tumor cells release larger amounts of these sHLA molecules, presumably to counter immune surveillance by T cells. Here we demonstrate that these sHLA molecules are still bound with their authentic peptide repertoires, similar to those of… CONTINUE READING