Soluble oligonucleosomal complexes in synovial fluid from inflamed joints.

  title={Soluble oligonucleosomal complexes in synovial fluid from inflamed joints.},
  author={De-min Yu and Peter Rumore and Qiang Liu and Charles R. Steinman},
  journal={Arthritis and rheumatism},
  volume={40 4},
OBJECTIVE To determine whether soluble oligonucleosomal DNA, typical of that released during apoptotic cell death, is present in synovial fluids from inflamed joints and, if so, whether it is present in sufficient concentrations to have pathophysiologic significance. METHODS Fifty synovial fluid specimens from 46 patients were studied, 41 from joints with a variety of inflammatory disorders and 9 from osteoarthritic joints. DNA from freshly collected synovial fluid was isolated and… CONTINUE READING
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