Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration.

  title={Soluble myelin-associated glycoprotein (MAG) found in vivo inhibits axonal regeneration.},
  author={Shaoqing Tang and R W Woodhall and Yingjie Shen and M E deBellard and Jane L. Saffell and Patrick Doherty and Frank S. Walsh and Marie T. Filbin},
  journal={Molecular and cellular neurosciences},
  volume={9 5-6},
Myelin-associated glycoprotein (MAG) is a potent inhibitor of axonal regeneration when used as a substrate for growth. However, to be characterized definitively as inhibitory rather than nonpermissive, MAG must also inhibit axonal regeneration when presented in solution. Here, we show that soluble dMAG (extracellular domain only), released in abundance from myelin and found in vivo and chimeric MAG-Fc, can potently inhibit axonal regeneration. For both dMAG and MAG-Fc, inhibition is dose… CONTINUE READING

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