Soluble monomeric IgG1 Fc.

Abstract

Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, compared with full-size antibodies, these antibody fragments lack the ability to bind the neonatal Fc receptor (FcRn) and have reduced half-lives. Fc engineered to bind antigens but preserve interactions with FcRn and… (More)
DOI: 10.1074/jbc.M112.368647

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Cite this paper

@article{Ying2012SolubleMI, title={Soluble monomeric IgG1 Fc.}, author={Tianlei Ying and Weizao Chen and Rui Gong and Yang Feng and Dimiter S. Dimitrov}, journal={The Journal of biological chemistry}, year={2012}, volume={287 23}, pages={19399-408} }