Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives.

@article{Anderson2017SolubleMA,
  title={Soluble membrane attack complex in the blood and cerebrospinal fluid of HIV-infected individuals, relationship to HIV RNA, and comparison with HIV negatives.},
  author={Albert M Anderson and Theresa N Schein and Aley G. Kalapila and Lillin Lai and Drenna Waldrop-Valverde and Raeanne C Moore and Donald R. Franklin and Scott L Letendre and Scott Robert Barnum},
  journal={Journal of neuroimmunology},
  year={2017},
  volume={311},
  pages={
          35-39
        }
}
The soluble membrane attack complex (sMAC) represents the terminal product of the complement cascade. We enrolled 47 HIV+ adults (12 of whom underwent a second visit at least 24weeks after starting therapy) as well as 11 HIV negative controls. At baseline, cerebrospinal fluid (CSF) sMAC was detectable in 27.7% of HIV+ individuals. CSF sMAC correlated with CSF HIV RNA levels and was more likely to be detectable in HIV+ individuals on cART compared to HIV negative controls. In HIV+ participants… CONTINUE READING