Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis.

@article{Daghestani2015SolubleMB,
  title={Soluble macrophage biomarkers indicate inflammatory phenotypes in patients with knee osteoarthritis.},
  author={Hikmat N. Daghestani and Carl F. Pieper and Virginia Byers Kraus},
  journal={Arthritis & rheumatology},
  year={2015},
  volume={67 4},
  pages={
          956-65
        }
}
OBJECTIVE To evaluate the ability of the macrophage markers CD163 and CD14 to predict different osteoarthritis (OA) phenotypes defined by severity of joint inflammation, radiographic features and progression, and joint pain. METHODS We evaluated 2 different cohorts totaling 184 patients with radiographic knee OA. These included 25 patients from a cross-sectional imaging study for whom there were data on activated macrophages in the knee joint, and 159 patients (134 with 3-year longitudinal… CONTINUE READING

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