Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques

@inproceedings{Kim2012SolubleIA,
  title={Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaques},
  author={J Kim and D. H. Kim and J H Kim and Duck Hyung Lee and Hyeongtag Jeon and S J Kwon and Sunphil Kim and Yung Joon Yoo and Eunjung Lee and Samjin Choi and Sang Won Seo and J. I. Lee and Duk L. Na and Young Yang and Wonjun Oh and Joonyeon Chang},
  booktitle={Cell Death and Differentiation},
  year={2012}
}
Presently, co-culture of human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) with BV2 microglia under amyloid-β42 (Aβ42) exposure induced a reduction of Aβ42 in the medium as well as an overexpression of the Aβ-degrading enzyme neprilysin (NEP) in microglia. Cytokine array examinations of co-cultured media revealed elevated release of soluble intracellular adhesion molecule-1 (sICAM-1) from hUCB-MSCs. Administration of human recombinant ICAM-1 in BV2 cells and wild-type mice brains… CONTINUE READING
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