Soluble interleukin-6 receptor alpha inhibits the cytokine-Induced fractalkine/CX3CL1 expression in human vascular endothelial cells in culture.

Abstract

Soluble form of IL-6 receptor alpha (sIL-6R) is known to serve as an agonist, without exogenous IL-6, on endothelial cells which do not express IL-6R but have only IL-6 receptor beta chain, gp130. We investigated the effect of sIL-6R on fractalkine expression in human umbilical vein endothelial cells (HUVECs) in culture. sIL-6R markedly inhibited HUVEC… (More)

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@article{Matsumiya2001SolubleIR, title={Soluble interleukin-6 receptor alpha inhibits the cytokine-Induced fractalkine/CX3CL1 expression in human vascular endothelial cells in culture.}, author={Takahiro Matsumiya and Tadaatsu Imaizumi and Kiyohide Fujimoto and Xiangjun Cui and Takahiro Shibata and Wakako Tamo and Masanobu Kumagai and K. Tanji and H. Yoshida and H. Kimura and K. Satoh}, journal={Experimental cell research}, year={2001}, volume={269 1}, pages={35-41} }