Soluble interleukin-6 receptor (sIL-6R) makes IL-6R negative T cell line respond to IL-6; it inhibits TNF production.

@article{Igaz2000SolubleIR,
  title={Soluble interleukin-6 receptor (sIL-6R) makes IL-6R negative T cell line respond to IL-6; it inhibits TNF production.},
  author={P{\'e}ter Igaz and Anna Horv{\'a}th and Barnab{\'a}s Horv{\'a}th and Cs Szalai and {\'E}va P{\'a}llinger and {\'E}va Rajnav{\"o}lgyi and Sara Toth and Stefan Rose-John and Andr{\'a}s Falus},
  journal={Immunology letters},
  year={2000},
  volume={71 3},
  pages={143-8}
}
The receptor for interleukin-6 (IL-6) consists of two subunits: a ligand specific IL-6Ralpha and gp130 that is responsible for signal-transduction. A soluble form of the ligand specific chain was described that when complexed to IL-6 is capable of binding to the membrane-bound gp130 subunit and thus can elicit signal-transduction. This soluble receptor can act on cells that express only the gp130 but not the ligand-specific subunit of the IL-6R. This phenomenon, called trans-signaling… CONTINUE READING

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