Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.

@article{Schbitz1995SolubleI,
  title={Soluble interleukin-6 (IL-6) receptor augments central effects of IL-6 in vivo.},
  author={B Sch{\"o}bitz and Gita Pezeshki and Thomas Pohl and Ulrike Hemmann and Peter Claus Heinrich and Florian Holsboer and Johannes M. H. M. Reul},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1995},
  volume={9 8},
  pages={659-64}
}
The pleiotropic cytokine interleukin-6 (IL-6) controls both the peripheral and central components of the acute-phase response. These activities are mediated via the IL-6 membrane receptor, but probably also via agonistic soluble IL-6 receptors (sIL-6Rs). In the present study we conducted dose-response experiments with rats that were intracerebroventricularly i.c.v.) injected with recombinant human IL-6 and sIL-6R and determined body temperature, locomotor activity, food intake, and water… CONTINUE READING