Soluble human leukocyte antigen--G serum level is elevated in melanoma patients and is further increased by interferon-alpha immunotherapy.

@article{Ugurel2001SolubleHL,
  title={Soluble human leukocyte antigen--G serum level is elevated in melanoma patients and is further increased by interferon-alpha immunotherapy.},
  author={Selma Ugurel and Vera Rebmann and Soldano Ferrone and Wolfgang Tilgen and Hans Grosse-Wilde and Uwe Reinhold},
  journal={Cancer},
  year={2001},
  volume={92 2},
  pages={369-76}
}
BACKGROUND The nonclassic human major histocompatibility complex class I antigens human leukocyte antigen (HLA)--G are proposed to protect tumor cells from natural killer cell lysis. In the current study, the authors measured soluble HLA-G molecules (sHLA-G) in serum from patients with malignant melanoma. METHODS Soluble HLA-G was determined in serum samples of 190 melanoma patients with various stages of disease, with or without current therapy including interferon (IFN)-alpha and different… CONTINUE READING