Soluble human IL-1 receptor type 2 inhibits ectopic endometrial tissue implantation and growth: identification of a novel potential target for endometriosis treatment.

@article{Khoufache2012SolubleHI,
  title={Soluble human IL-1 receptor type 2 inhibits ectopic endometrial tissue implantation and growth: identification of a novel potential target for endometriosis treatment.},
  author={Khaled Khoufache and Patrick Kibangou Bondza and Noria Harir and Marleen Daris and Mathieu Leboeuf and Jacques Mailloux and Madeleine Lemyre and Warren Foster and Ali Akoum},
  journal={The American journal of pathology},
  year={2012},
  volume={181 4},
  pages={1197-205}
}
Endometriosis is often associated with a chronic pelvic immuno-inflammatory process, which is closely related to disease pathogenesis and major symptoms. Our studies led to the detection of a marked imbalance between IL-1 and its natural inhibitor IL-1 receptor type 2 (IL1R2) in women with endometriosis. This points to a deficiency in the local control of IL-1 that, in view of the cytokine's elevated levels and potent proinflammatory, angiogenic, and growth-promoting effects, may contribute to… CONTINUE READING

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