Soluble human CD83 ameliorates lupus in NZB/W F1 mice.

  title={Soluble human CD83 ameliorates lupus in NZB/W F1 mice.},
  author={Charlotte Starke and Alexander Steinkasserer and Reinhard Edmund Voll and Elisabeth Zinser},
  volume={218 11},
In the present study we explored the immunomodulatory potential of prokaryotically expressed soluble CD83 in the treatment of murine lupus using the NZB/W F1 mouse model. Therefore female NZB/W F1 lupus mice were treated either with sCD83 or PBS for 4 weeks. sCD83 treated mice showed a significantly delayed onset of anti-dsDNA autoantibody production when compared with the control group. Importantly, during the treatment period with sCD83 none of the mice showed elevated levels of anti-dsDNA… CONTINUE READING