Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury.

  title={Soluble guanylyl cyclase expression is reduced in LPS-induced lung injury.},
  author={Constantinos Glynos and Anastasia N. Kotanidou and Stylianos E. Orfanos and Zongmin Zhou and Davina C M Simoes and Christina Magkou and Charis Roussos and Andreas Papapetropoulos},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={292 4},
Soluble guanylyl cyclase (sGC) is a cGMP-generating enzyme implicated in the control of smooth muscle tone that also regulates platelet aggregation. Moreover, sGC activation has been shown to reduce leukocyte adherence to the endothelium. Herein, we investigated the expression of sGC in a murine model of LPS-induced lung injury and evaluated the effects of sGC inhibition in the context of acute lung injury (ALI). Lung tissue sGC alpha1 and beta1 subunit protein levels were determined by Western… CONTINUE READING


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