Soluble guanylate cyclase modulators blunt hyperoxia effects on calcium responses of developing human airway smooth muscle.

@article{Britt2015SolubleGC,
  title={Soluble guanylate cyclase modulators blunt hyperoxia effects on calcium responses of developing human airway smooth muscle.},
  author={Rodney D. Britt and Michael Allen Thompson and Ine Kuipers and Alecia L. Stewart and Elizabeth R. Vogel and James Thu and Richard J. Martin and Christina M. Pabelick and Y S Prakash},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2015},
  volume={309 6},
  pages={L537-42}
}
Exposure to moderate hyperoxia in prematurity contributes to subsequent airway dysfunction and increases the risk of developing recurrent wheeze and asthma. The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic GMP (cGMP) axis modulates airway tone by regulating airway smooth muscle (ASM) intracellular Ca(2+) ([Ca(2+)]i) and contractility. However, the effects of hyperoxia on this axis in the context of Ca(2+)/contractility are not known. In developing human ASM, we explored the effects… CONTINUE READING