Soluble guanylate cyclase.

Abstract

Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep mechanism of sGC activation that involves at least two NO-binding sites. The crystal structure of a member of a recently discovered family of prokaryotic sGC homologues has provided important insights into structure-function relationships within the sGC family of proteins.

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@article{Poulos2006SolubleGC, title={Soluble guanylate cyclase.}, author={Thomas L Poulos}, journal={Current opinion in structural biology}, year={2006}, volume={16 6}, pages={736-43} }