Soluble gp130 promotes intestinal epithelial hyperplasia during reovirus infection.

  title={Soluble gp130 promotes intestinal epithelial hyperplasia during reovirus infection.},
  author={Dina Montufar-Solis and Tomas Garza and N Vigneswaran and John R. Klein},
  journal={International journal of experimental pathology},
  volume={91 3},
Soluble gp130 (sgp130) has been shown to suppress the inflammatory response of autoimmune pathologies; however, its effects on virus infection are not known. Here, we report that intraperitoneal treatment of mice with sgp130-Fc fusion protein at the time of oral reovirus serotype 3 infection resulted in altered morphopathological changes that were evident by less shortening of intestinal villi length and crypt depth after infection. That the effect mediated by sgp130 treatment was due to an… CONTINUE READING

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