Soluble forms of intercellular adhesion molecule-1 inhibit insulitis and onset of autoimmune diabetes

@article{Martin1998SolubleFO,
  title={Soluble forms of intercellular adhesion molecule-1 inhibit insulitis and onset of autoimmune diabetes},
  author={Stephan Martin and Edmund Heidenthal and Bernd Schulte and Helga Rothe and Hubert Kolb},
  journal={Diabetologia},
  year={1998},
  volume={41},
  pages={1298-1303}
}
Increased concentration of circulating adhesion molecules in human serum have been described in different immune-mediated diseases. Recently, we proposed an immunomodulatory function of soluble forms of the intercellular adhesion molecule-1 (ICAM-1) during the pathogenesis of human Type I (insulin-dependent) diabetes mellitus. To test this hypothesis in nonobese diabetic (NOD) mice, a spontaneous animal model for human Type I diabetes, two recombinant forms of soluble murine ICAM-1 were… CONTINUE READING