Soluble forms of RAGE in internal medicine.

  title={Soluble forms of RAGE in internal medicine.},
  author={Natale Vazzana and Francesca Santilli and Chiara Cuccurullo and Giovanni Dav{\'i}},
  journal={Internal and emergency medicine},
  volume={4 5},
The receptor for advanced glycation end-products (RAGE) and its ligands are intimately involved in the pathobiology of a wide range of diseases that share common features, such as enhanced oxidative stress, immune/inflammatory responses, and altered cell functions. Soluble forms of RAGE (sRAGE), including the splice variant endogenous secretory (es)RAGE, have been found circulating in plasma and tissues. Experimental data suggest that these isoforms may neutralize the ligand-mediated damage by… CONTINUE READING