Soluble expression of active recombinant human tissue plasminogen activator derivative (K2S) in Escherichia coli.

Abstract

CONTEXT The kringle 2 plus serine protease domains (K2S) of human tissue plasminogen activator (tPA) is an efficacious thrombolytic drug, which has been used to treat heart attacks and strokes by breaking up the clots that cause them. It has nine disulfide bridges, which are needed for proper folding and be the bottleneck in improving the production in the… (More)
DOI: 10.3109/13880209.2010.531482

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