Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation

  title={Soluble epoxide hydrolase limits mechanical hyperalgesia during inflammation},
  author={Christian Brenneis and Marco Sisignano and Ovidiu Coste and Kai Altenrath and Michael J M Fischer and Carlo Angioni and Ingrid Fleming and Ralf Peter Brandes and Peter W Reeh and Clifford J Woolf and Gerd 7 Geisslinger and Klaus Scholich},
  booktitle={Molecular pain},
BACKGROUND Cytochrome-P450 (CYP450) epoxygenases metabolise arachidonic acid (AA) into four different biologically active epoxyeicosatrienoic acid (EET) regioisomers. Three of the EETs (i.e., 8,9-, 11,12- and 14,15-EET) are rapidly hydrolysed by the enzyme soluble epoxide hydrolase (sEH). Here, we investigated the role of sEH in nociceptive processing during peripheral inflammation. RESULTS In dorsal root ganglia (DRG), we found that sEH is expressed in medium and large diameter neurofilament… CONTINUE READING
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