Soluble epoxide hydrolase inhibitors and cardiovascular diseases.

  title={Soluble epoxide hydrolase inhibitors and cardiovascular diseases.},
  author={Zhen-he Wang and Benjamin B. Davis and De-qian Jiang and Ting-ting Zhao and Danyan Xu},
  journal={Current vascular pharmacology},
  volume={11 1},
BACKGROUND Epoxyeicosatrienoic acids (EETs) have been shown to play a role in cardiovascular protection by reducing ischemia reperfusion injury, producing anti-inflammatory effects, and promoting angiogenesis. EETs are regulated through conversion to less active corresponding diols by soluble epoxide hydrolase (sEH). Inhibition of sEH enhances the beneficial properties of EETs and has been investigated as a possible treatment for cardiovascular diseases. CONTENT sEH inhibitors (sEHIs) have… CONTINUE READING