Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex

@inproceedings{Wu2015SolubleEH,
  title={Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex},
  author={Han-Fang Wu and Hsin-Ju Yen and Chi-Chen Huang and Yi-Chao Lee and Su-zhen Wu and Tzong-Shyuan Lee and Hui-Ching Lin},
  booktitle={Journal of Biomedical Science},
  year={2015}
}
The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs). sEH inhibition (sEHI) has proven to be protective against experimental cerebral ischemia, and it is emerging as a therapeutic target for prevention and treatment of ischemic stroke. However, the role of sEH on synaptic function in the central nervous system is still largely unknown. This study aimed to test whether sEH C… CONTINUE READING
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