Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.

@article{Zhao2004SolubleEH,
  title={Soluble epoxide hydrolase inhibition protects the kidney from hypertension-induced damage.},
  author={Xueying Zhao and Tatsuo Yamamoto and John W. Newman and In-Hae Kim and Takaho Watanabe and Bruce D Hammock and Janet Kidd Stewart and Jennifer S. Pollock and David M Pollock and John D. Imig},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2004},
  volume={15 5},
  pages={1244-53}
}
Epoxyeicosatrienoic acids (EET) have antihypertensive and anti-inflammatory properties and play a role in the maintenance of renal vascular function. A novel approach to increase EET levels is to inhibit epoxide hydrolase enzymes that are responsible for conversion of biologically active EET to dihydroxyeicosatrienoic acids (DHET). We hypothesized that soluble epoxide hydrolase (SEH) inhibition would improve renal vascular function and ameliorate hypertension induced renal damage. Chronic… CONTINUE READING
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