Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception.

@article{Wagner2011SolubleEH,
  title={Soluble epoxide hydrolase inhibition, epoxygenated fatty acids and nociception.},
  author={Karen M. Wagner and Bora Inceoğlu and Bruce D Hammock},
  journal={Prostaglandins & other lipid mediators},
  year={2011},
  volume={96 1-4},
  pages={76-83}
}
The soluble epoxide hydrolase (sEH) enzyme regulates the levels of endogenous epoxygenated fatty acid (EFA) lipid metabolites by rapidly degrading these molecules. The EFAs have pleiotropic biological activities including the modulation of nociceptive signaling. Recent findings indicate that the EFAs, in particular the arachidonic acid (AA) derived epoxyeicosatrienoic acids (EETs), the docosahexaenoic acid (DHA) derived epoxydocosapentaenoic acids (EpDPEs) and eicosapentaenoic acid (EPA… CONTINUE READING

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