Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

@article{Zhang2008SolubleEH,
  title={Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.},
  author={Wenri Zhang and Takashi Otsuka and Nobuo Sugo and Ardi Ardeshiri and Yazan Alhadid and Jeffrey J Iliff and Andrea E Debarber and Dennis R. Koop and Nabil J. Alkayed},
  journal={Stroke},
  year={2008},
  volume={39 7},
  pages={2073-8}
}
BACKGROUND AND PURPOSE Cytochrome P450 epoxygenase metabolizes arachidonic acid to epoxyeicosatrienoic acids (EETs). EETs are produced in the brain and perform important biological functions, including vasodilation and neuroprotection. However, EETs are rapidly metabolized via soluble epoxide hydrolase (sEH) to dihydroxyeicosatrienoic acids (DHETs). We tested the hypothesis that sEH gene deletion is protective against focal cerebral ischemia through enhanced collateral blood flow. METHODS sEH… CONTINUE READING

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