Soluble epoxide hydrolase: a novel therapeutic target in stroke.

  title={Soluble epoxide hydrolase: a novel therapeutic target in stroke.},
  author={Wenri Zhang and Ines P. Koerner and Ruediger R Noppens and Marjorie R. Grafe and Hsing-Ju Tsai and Christophe H P Morisseau and Ayala Luria and Bruce D Hammock and John R Falck and Nabil J. Alkayed},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  volume={27 12},
The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are produced in brain and perform important biological functions, including protection from ischemic injury. The beneficial effect of EETs, however, is limited by their metabolism via soluble epoxide hydrolase (sEH). We tested the hypothesis that sEH inhibition is protective against ischemic brain damage… CONTINUE READING