Soluble endoglin contributes to the pathogenesis of preeclampsia

@article{Venkatesha2006SolubleEC,
  title={Soluble endoglin contributes to the pathogenesis of preeclampsia},
  author={Shivalingappa Venkatesha and Mourad Toporsian and Chun Lam and Jun-ichi Hanai and Tadanori Mammoto and Yeon Kim and Yuval Bdolah and Kee-Hak Lim and Hai-tao Yuan and T. A. Libermann and Isaac E Stillman and Drucilla J Roberts and Patricia A D'Amore and Franklin H. Epstein and Frank W Sellke and Roberto Romero and Vikas P Sukhatme and Michelle Letarte and Siddharth Karumanchi},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={642-649}
}
Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by excess placenta-derived soluble VEGF receptor 1 (sVEGFR1 or sFlt1) is emerging as a prominent component in disease pathogenesis. We report a novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery… CONTINUE READING
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