Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

  title={Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes},
  author={Myung-hyun Yim and Jang-woo Shin and Jin-young Son and Se-mi Oh and Seung-hyun Han and Jung-Hyo Cho and Chong-kwan Cho and Hwa-Seung Yoo and Yeon-weol Lee and Chang-Gue Son},
  journal={Acta Pharmacologica Sinica},
AbstractAim:To investigate the immunoregulatory functions of water extracts of Hericium erinaceum (WEHE) focusing on natural killer (NK) cell-based anticancer activities.Methods:Mouse splenocytes or purely isolated NK cells were stimulated with 1-100 mg/L WEHE for 24 h followed by co-culture with 51Cr-labled Yac-1 cells for 4 h, then NK cell-derived cytolytic activity was measured using a radio-release assay. Neutralizing antibodies against mouse interleukin-12 (IL-12) were added into the WEHE… CONTINUE READING
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