Soluble beta-galactosyl-binding lectin (galectin) from toad ovary: crystallographic studies of two protein-sugar complexes.

@article{Bianchet2000SolubleBL,
  title={Soluble beta-galactosyl-binding lectin (galectin) from toad ovary: crystallographic studies of two protein-sugar complexes.},
  author={Mario A Bianchet and Hatim Rahamtalla Mohamed Ahmed and Gerardo Raul Vasta and L. Mario Amzel},
  journal={Proteins},
  year={2000},
  volume={40 3},
  pages={378-88}
}
Galectin-1, S-type beta-galactosyl-binding lectins present in vertebrate and invertebrate species, are dimeric proteins that participate in cellular adhesion, activation, growth regulation, and apoptosis. Two high-resolution crystal structures of B. arenarum galectin-1 in complex with two related carbohydrates, LacNAc and TDG, show that the topologically equivalent hydroxyl groups in the two disaccharides exhibit identical patterns of interaction with the protein. Groups that are not equivalent… CONTINUE READING

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