Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1

@inproceedings{Morgese2015SolubleBA,
  title={Soluble beta amyloid evokes alteration in brain norepinephrine levels: role of nitric oxide and interleukin-1},
  author={Maria Grazia Morgese and Marilena Colaianna and Emanuela Mhillaj and Margherita Zotti and Stefania Schiavone and Palma Pia D'Antonio and Andrew Harkin and Valentina Gigliucci and Patrizia Campolongo and Viviana Trezza and Angelo De Stradis and Paolo Tucci and Vincenzo Cuomo and Luigia Trabace},
  booktitle={Front. Neurosci.},
  year={2015}
}
Strong evidence showed neurotoxic properties of beta amyloid (Aβ) and its pivotal role in the Alzheimer's disease (AD) pathogenesis. Beside, experimental data suggest that Aβ may have physiological roles considering that such soluble peptide is produced and secreted during normal cellular activity. There is now suggestive evidence that neurodegenerative conditions, like AD, involve nitric oxide (NO) in their pathogenesis. Nitric oxide also possess potent neuromodulatory actions in brain regions… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-8 OF 8 CITATIONS

Antidepressant drugs for beta amyloid-induced depression: A new standpoint?

  • Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS

References

Publications referenced by this paper.
SHOWING 1-10 OF 72 REFERENCES

Involvement of the nitric oxide

A. Palmeri, O. Arancio
  • 2006
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1998
VIEW 1 EXCERPT
HIGHLY INFLUENTIAL

Soluble ß-amyloid and norepinephrine

X. Liu, K. Ye, D. Weinshenker
  • 2015
VIEW 1 EXCERPT