Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning.

@article{Holscher2007SolubleBR,
  title={Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning.},
  author={Christian Holscher and Simon Gengler and Victor A Gault and Patrick Harriott and Hanspeter A. Mallot},
  journal={European journal of pharmacology},
  year={2007},
  volume={561 1-3},
  pages={85-90}
}
Beta-amyloid is a peptide that appears to be responsible for cognitive impairments in patients with Alzheimer's disease. Recent research shows that soluble oligomers of beta-amyloid affect synaptic activity and learning, well before any amyloid has aggregated into plaques. Here we show that injection of 3x10 nmol amyloid [25-35] i.c.v. transiently impairs learning of a radial arm maze and the induction of hippocampal long-term potentiation. Furthermore, hippocampal field potentials had been… CONTINUE READING

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