Soluble apoptosis molecules in primary biliary cirrhosis: analysis and commitment of the Fas and tumour necrosis factor-related apoptosis-inducing ligand systems in comparison with chronic hepatitis C.

@article{Pelli2007SolubleAM,
  title={Soluble apoptosis molecules in primary biliary cirrhosis: analysis and commitment of the Fas and tumour necrosis factor-related apoptosis-inducing ligand systems in comparison with chronic hepatitis C.},
  author={Nicoletta Pelli and Annarosa Floreani and Francesco Dalla Torre and Andrea Delfino and Anna Maria Baragiotta and Paola Contini and Monica Basso and Antonino Picciotto},
  journal={Clinical and experimental immunology},
  year={2007},
  volume={148 1},
  pages={85-9}
}
Apoptosis in the liver is generated mainly by the Fas system. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has been proposed recently as a new apoptotic inducer. In the liver environment hepatocytes and biliary epithelial cells express TRAIL receptors which are up-regulated by increased levels of bile acids and during viral hepatitis. As for FasL, a soluble form of TRAIL has been described. To explore the commitment and level of activation of these two apoptotic systems in… CONTINUE READING