Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats

@article{Thornton2006SolubleAP,
  title={Soluble amyloid precursor protein α reduces neuronal injury and improves functional outcome following diffuse traumatic brain injury in rats},
  author={Emma Thornton and Robert Vink and Peter Charles Blumbergs and Corinna van den Heuvel},
  journal={Brain Research},
  year={2006},
  volume={1094},
  pages={38-46}
}
Amyloid precursor protein (APP) has previously been shown to increase following traumatic brain injury (TBI). Whereas a number of investigators assume that increased APP may lead to the production of neurotoxic Abeta and be deleterious to outcome, the soluble alpha form of APP (sAPPalpha) is a product of the non-amyloidogenic cleavage of amyloid precursor protein that has previously been shown in vitro to have many neuroprotective and neurotrophic functions. However, no study to date has… CONTINUE READING

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