Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.

@article{Jin2011SolubleAB,
  title={Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.},
  author={Ming Jin and Nina E. Shepardson and Ting Yang and Gang Chen and Dominic Walsh and Dennis J Selkoe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 14},
  pages={5819-24}
}
Alzheimer disease is a major cause of cognitive failure, and a pathogenically related but more subtle process accounts for many cases of mild memory symptoms in older humans. Insoluble fibrillar plaques of amyloid β-proteins (Aβ) and neurofibrillary deposits of hyperphosphorylated tau proteins are the diagnostic lesions of AD, but their temporal mechanistic relationship has long been debated. The recent recognition that small, diffusible oligomers may be the principal bioactive form of A… CONTINUE READING
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