Soluble adhesion molecules in human cancers: sources and fates.

  title={Soluble adhesion molecules in human cancers: sources and fates.},
  author={Jeroen W J van Kilsdonk and L{\'e}on C van Kempen and Goos N. P. van Muijen and Dirk J. Ruiter and Guido W. M. Swart},
  journal={European journal of cell biology},
  volume={89 6},
Adhesion molecules endow tumor cells with the necessary cell-cell contacts and cell-matrix interactions. As such, adhesion molecules are involved in cell signalling, proliferation and tumor growth. Rearrangements in the adhesion repertoire allow tumor cells to migrate, invade and form metastases. Besides these membrane-bound adhesion molecules several soluble adhesion molecules are detected in the supernatant of tumor cell lines and patient body fluids. Truncated soluble adhesion molecules can… CONTINUE READING
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