Soluble adenylyl cyclase is not required for axon guidance to netrin-1.

  title={Soluble adenylyl cyclase is not required for axon guidance to netrin-1.},
  author={Simon W. Moore and Karen Lai Wing Sun and Fang Xie and Phillip A Barker and Marco Conti and Timothy E Kennedy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={28 15},
During development, axons are directed to their targets by extracellular guidance cues. The axonal response to the guidance cue netrin-1 is profoundly influenced by the concentration of cAMP within the growth cone. In some cases, cAMP affects the sensitivity of the growth cone to netrin-1, whereas in others it changes the response to netrin-1 from attraction to repulsion. The effects of cAMP on netrin-1 action are well accepted, but the critical issue of whether cAMP production is activated by… CONTINUE READING


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