Soluble adenylyl cyclase is essential for proper lysosomal acidification

  title={Soluble adenylyl cyclase is essential for proper lysosomal acidification},
  author={Nawreen Rahman and Lavoisier Ramos-Espiritu and Teresa A. Milner and Jochen Buck and Lonny R. Levin},
  journal={The Journal of General Physiology},
  pages={325 - 339}
Lysosomes are the main degradative compartment in cells and require an acidic luminal environment for correct function. Rahman et al. show that soluble adenylyl cyclase is required for localization of the V-ATPase proton pump to lysosomes and therefore lysosomal acidification and function. 

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